In a saucepan, combine apple cider vinegar, ketchup, brown sugar, Worcestershire sauce, Dijon mustard, garlic powder, onion powder, smoked paprika, salt, and pepper.
Bring the mixture to a simmer over medium heat, stirring occasionally.
Reduce heat to low and let the sauce simmer for about 15-20 minutes, stirring occasionally, until it thickens slightly.
Taste the sauce and adjust seasoning if needed.
Remove from heat and let it cool before using it as a marinade or drizzling over grilled meats.
Enjoy!